CinnaDent - Plant-based substances against tooth decay
Technology description
| The name of the technology: | CinnaDent - Plant-based substances against tooth decay |
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| Challenge: | The use of natural substances in areas such as cosmetics and hygiene products has been a highly discussed issue in recent years. In the case of using such natural raw materials that can also be obtained locally or at the place of production, such production also represents a very ecological approach. |
| Description: |
During our research into natural products at Palacký University in Olomouc, we found that a blend of a cinnamic acid derivative with a certain plant extract exhibits synergistic antimicrobial activity against S. mutans and other microorganisms involved in producing dental cavities. This mixture is therefore suitable for use in mouthwashes and toothpastes. The effect of such hygiene products show comparable or better effects than commonly used substances, with the added value of the synergistic effect of both components and the use of locally produced crops and natural substances. Since obtaining these derivatives from natural sources is not economically viable, we developed a synthetic production method that allows for larger-scale production while maintaining acceptable production costs. The produced derivatives were subjected to thorough testing together with natural plant extracts, and we demonstrated their effectiveness. We verified this effectiveness with two functional prototypes , which showed the possibility of practical use in the composition of mouthwash and toothpaste. The testing included in vitro skin irritation tests, tests of the effectiveness of the preservative system, cytotoxicity, stability studies, and sensory tests, focusing mainly on taste. The results of these tests confirmed not only the functionality of the individual components but also their suitability for final processing into products. |
| Commercial opportunity: | For commercial applications, our primary focus is on manufacturers of hygiene products, such as mouthwash, toothpaste, and similar items. With its natural origin and effectiveness that matches or surpasses commonly used substances, it represents an outstanding and innovative alternative. |
| IP protection status: |
Patent - CZ 309633 International application PCT/CZ2020/050011 European patent application EP20714469.2 |
| Development status: |
Phase 3Corresponds with TRL 5 and TRL 6 Technology validation and implementing it in real environment. Testing the technology outside of the laboratory and its adjustment to external conditions.
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| Partnering strategy: | Collaboration licensing |
| More information: | Our intention is to find a commercial partner in the field of toothpaste production with plant extracts with limited or no use of chemicals, who would exploit the potential of the proven synergistic effect of the developed cinnamic acid derivative and plant extracts. |
| Images: | No picture inserted |
| Categories: | Production of food products |
| Owner of a technology: | Univerzita Palackého v Olomouci |
