OncoLipidomics - MS analysis for early diagnosis of pancreatic cancer

Technology description

The name of the technology: OncoLipidomics - MS analysis for early diagnosis of pancreatic cancer
Challenge: No screening tests have so far been developed that would allow the detection of sufficiently early stages to lower the risk of dying from pancreatic cancer. So far, several types of blood tests have been considered to diagnose pancreatic cancer, such as carbohydrate antigen 19–9 (CA19-9), carcinoembryonic antigen (CEA), or Kirsten-ras (KRAS), but unfortunately low sensitivity and low specificity do not allow their use in the clinical practice for early diagnosis. The aim of our project is to develop a technology for the early stage detection of pancreatic cancer.
Description: The mass spectrometry (MS) based lipid profiling of body fluid samples of pancreatic cancer patients and healthy volunteers enables to build up the statistical models, which are used to determine the level of probability of the patient suffering from pancreatic cancer. The methodology is based on liquid chromatography MS analysis of up to 500 lipids (UHPSFC/MS, shotgun MS, MALDI). The resulting lipidomic pattern enables to discriminate between cancer patients and healthy volunteers. The retrospective validation study with nearly 400 samples was performed in the Czech Republic and discriminated pancreatic cancer patients of all stages from healthy controls.
• detection of early curable stages T1, T2 (95 -100% accuracy)
• 10,000 samples / one year / one MS system
• only 10 - 25 µl of serum or plasma needed
• the method is suitable for high-throughput screening
• validated in line with recommendations of FDA and EMEA
Commercial opportunity: Our major goal is to transfer our know-how into a commercial product, which shall be ready-to-use in clinical screening of pancreatic cancer, including subsequent diagnostics by conventional medical approaches. We offer a unique technology and outstanding expertise in LS MS analysis. We are looking for a co-development or licencing partner for commercialization on a global scale.
IP protection status: 1st EP application filed 1/2018, 2nd EP application filed 5/2018, PCT filed 11/2018
Development status:

Phase 3

Corresponds with TRL 5 and TRL 6

Technology validation and implementing it in real environment. Testing the technology outside of the laboratory and its adjustment to external conditions.

  • TRL 5 represents a state where the results of the real environment tests are known and there is an idea of how to deal with the problems found (if any)
  • TRL 6 is a state where a fully functional prototype already exists and is capable of fulfilling all its functions
Partnering strategy: Co-development Collaboration licensing
More information:
Images: No picture inserted
Keywords: cancer diagnostic lipid mass spectrometry pancreatic cancer
Categories: Pharma Life Science and Health Chemistry
Owner of a technology: Univerzita Pardubice
Institution: University of Pardubice
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