Light activated nanomaterials fighting infections

Technology description

The name of the technology: Light activated nanomaterials fighting infections
Challenge: Infections that are causally linked to hospitalization of patients are a global problem, especially in developing countries. The basic feature of these infections is increased resistance to antimicrobials and disinfectants. The LAM-X academic spin-off was established to develop nanomaterials useful in the fight against these diseases.
Description: LAM-X develops active nanomaterials that effectively eliminate a wide range of infectious agents trapped on their surfaces. The antimicrobial effect of LAM-X membranes is ensured by a highly reactive form of oxygen (singlet oxygen), which is produced during irradiation with normal visible light. Due to the rate and mechanism of action of singlet oxygen, no antimicrobial resistance develops. The antimicrobial and antiviral activity of the membrane was demonstrated in vitro (E. coli, Staphyl. Aureus, baculoviruses, polyomaviruses). The LAM-X membrane was also successfully tested during a clinical study focused on the treatment of chronic wounds.
Commercial opportunity: LAM-X platform technology can be used in a wide range of applications such as treatment of chronic wounds and burns (wound dressings), disinfection and sterilization of hospital surfaces (filters, self-sterilizing surfaces), food / medical device protection (antimicrobial packaging) . The priority prototype developed by LAM-X is a wound dressings. In response to the global threat of COVID-19, the company is developing anti-virus self-sterilizing filters that can be repetitively used as part of face masks.
IP protection status: CZ patent (CZ303243B6), PCT applications in preparation
Development status:

Phase 3

Corresponds with TRL 5 and TRL 6

Technology validation and implementing it in real environment. Testing the technology outside of the laboratory and its adjustment to external conditions.

  • TRL 5 represents a state where the results of the real environment tests are known and there is an idea of how to deal with the problems found (if any)
  • TRL 6 is a state where a fully functional prototype already exists and is capable of fulfilling all its functions
Partnering strategy: Collaboration investment licensing
More information: Arenbergerova, M., Arenberger, P., Bednar, M., Kubat, P. & Mosinger, J. Light-activated nanofibre textiles exert antibacterial effects in the setting of chronic wound healing. Exp. Dermatol. 21, 619–624 (2012).
Images: No picture inserted
Keywords: active materials antimicrobial materials antimicrobial resistence singlet oxygen
Categories: Medical Devices
Owner of a technology: LAM-X a.s. (LAM-X je akademický spin-off založený společnostmi i&i Prague s.r.o. a CUIP s.r.o)
Institution: i&i Prague
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